Health Care Professionals

Hodges Family

p6 bottlePrincipal 6 Fertility is a revolutionary fertility supplement. Created by Dr. Hodges, Principal 6 Fertility is a comprehensive formulation based on years of scientific research in reproductive medicine. The ingredients are consistent with ACOG recommendations (American Congress of Obstetricians and Gynecologists) and data specifically investigating ways to improve IVF (in vitro fertilization) success rates.


How Our 6 Core Ingredients Improve Fertility


How Principal 6 Compares to Others



We based our fertility supplement and prenatal vitamin on the clinical guidelines of ACOG (the American Congress of Obstetricians and Gynecologists), the Mayo Clinic, and the most current reproductive and fertility research. Below are preconception / pregnancy recommendations from ACOG and the Mayo Clinic and how they compare to all of the ingredients in Principal 6 Fertility Supplement and Principal 6 Prenatal Vitamin.

How Our Ingredients Compare to Recommendations from ACOG and the Mayo Clinic

The aim of Principal 6 Fertility Supplement is to significantly improve reproductive outcomes. The ingredients are based on numerous studies. To offer a more comprehensive approach to reproductive health, we created Principal 6 Prenatal. Our prenatal vitamin meets all the recommendations set forth by ACOG and the Mayo Clinic. For best results, we recommend that women take both the fertility supplement and prenatal vitamin together in the pre-conception period. Research shows that best results are seen after 90 days of supplementation. Once pregnant, patients need to stop taking Principal 6 Fertility due to the DHEA that is contained within the supplement. There is some data that shows potential risk for birth defects if DHEA is taken while pregnant.


How Our 6 Core Ingredients Improve Fertility

Ingredient Dose Science
5-DHEA 75 mg The best studies look at using 75mg. Improves egg quality, improves birth rate, improved IVF cycles, beneficial effect on ovarian reserves
CoEnzyme Q10 200 mg Improves ovarian response and semen quality (when men take it)
Myo-Inositol 2000 mg Helps support ovulatory function, improves egg quality
Tetra-hydrofolate (best formulation of folic acid) 900 mcg Improves embryo implantation and decreases risk birth/brain defects in growing fetus; ladies need folic acid, tetra-hydrofolate is just the best formulation
Vitamin D3 2000 IU Increases pregnancy rates and ovulatory function – particularly in IVF cycles; Vit D receptors are found in reproductive tissues: so it helps regulate any metabolic disturbances that can effect pregnancy.
Krill Oil (best source of Omega 3 fatty acids) 917 mg Increases pregnancy rates and ovulatory function
Principal 6 Compared

How Our Ingredients Compare to Recommendations from ACOG and the Mayo Clinic

Ingredient Preferred Form of Ingredient ACOG Recommendations Mayo Clinic Recommendations Principal 6 Fertility Principal 6 Prenatal
Folate L-5-methyltetrahydro-folate 400 – 600 mcg 400 – 900 mcg 900 mcg* 800 mcg**
DHEA 75mg
Co Q 10 200mg
Myo-inositol 2g
Krill Oil/DHA DHA 20%, EPA 4% 917 mg
Vitamin D3 Cholecalciferol 400 IU 2000 IU 500 IU
Iron Ferrous Fumarate 27 mg 30 mg 27 mg
Calcium 1000 mg 250 mg 550 mg
Zinc Zinc Amino Acid Chelate 15 mg 15 mg
Vitamin A Beta Carotene 5000 mg
Vitamin B1 Thiamine HCl 1.7 mg
Vitamin B6 Pyridoxine HCl 2 mg 2.5 mg
Vitamin B12 Cyanocobalamin 8 mcg
Vitamin C Ascorbic Acid 50 mg 120 mg
Vitamin E Natural DL-Alpha-Tocopheryl Acetate 30 IU
Riboflavin 2 mg
Niacin Niacinamide 20 mg
Biotin 300 mcg
Pantothenic Acid Calcium D-Pantothenate 10 mg
Iodine Potassium Iodide 150 mcg
Magnesium Magnesium Oxide 50 mg
Zinc Zinc Oxide 15 mg 15 mg
Copper Copper Chelate 2 mg 2 mg

* As Tetrahydrofolate
** As Folic Acid


Research Data for the Ingredients of Principal 6 Fertility Supplement

Has been shown to have improved embryo quality (particularly in women with poor ovarian reserves) & Have higher live birth rates

  1. A. Wiser*, O. Gonen, Y. Ghetler, T. Shavit, A. Berkovitz and A. Shulman. Addition of dehydroepiandrosterone (DHEA) for poor-responder patients before and during IVF treatment improves the pregnancy rate: A randomized prospective study. Hum. Reprod. (2010) 25 (10): 2496-2500.
  2. David Barad and Norbert Gleicher. Effect of dehydroepiandrosterone on oocyte and embryo yields, embryo grade and cell number in IVF. Hum. Reprod. (2006) 21 (11): 2845-2849.
  3. David Barad, Hyama Brill, Norbert Gleicher. Update on the use of dehydroepiandrosterone supplementation among women with diminished ovarian function. Journal of Assisted Reproduction and Genetics . December 2007, Volume 24, Issue 12, pp 629-634

Co-Enzyme Q10
Improves Ovarian response & CoQ10 supplementation improves semen quality with beneficial effect on pregnancy rate

  1. E. Burstein, A. Perumalsamy, Y. Bentov, N. Esfandiari, A. Jurisicova, R.F. Casper. Co-enzyme Q10 supplementation improves ovarian response and mitochondrial function in aged mice. Fertility and Sterility, Volume 92, Issue 3, Supplement, Page S31, September 2009
  2. Mohammad Reza Safarinejad. The effect of coenzyme Q10 supplementation on partner pregnancy rate in infertile men with idiopathic oligoasthenoteratozoospermia: an open-label prospective study. International Urology and Nephrology, June 2012, Volume 44, Issue 3, pp 689-700

Helps support ovulatory function & Improves quality of eggs

  1. E. Papaleo, V. Unfer , J.P. Baillargeon, T.T. Chiu. Contribution of myo-inositol to reproduction. European Journal of Obstetrics & Gynecology and Reproductive Biology, Volume 147, Issue 2 , Pages 120-123, December 2009

Though the recommendation for pregnancy is 400-600mcg of folate/folic acid, this is the minimal amount needed to prevent birth defects. But 800-1200 mcg of tetrahydrofolate is best.

Vitamin D3 and Krill Oil
Anti-oxidant properties to help with ovulatory function & improved IVF and pregnancy success

  1. Sebiha Ozkan, M.D.a, Sangita Jindal, Ph.D.b,, Keri Greenseid, M.D.b, Jun Shu, M.D.c, Gohar Zeitlian, M.D.b, Cheryl Hickmon, B.S.b, Lubna Pal, M.B., B.S. Replete vitamin D stores predict reproductive success following in vitro fertilization. Fertility and Sterility, Volume 94, Issue 4, September 2010, Pages 1314–1319