Our Supplement

Principal 6 Fertility is a revolutionary fertility supplement. Created by Dr. Hodges, Principal 6 Fertility is a comprehensive formulation based on years of scientific research in reproductive medicine. The ingredients are consistent with ACOG recommendations (American Congress of Obstetricians and Gynecologists) and data specifically investigating ways to improve IVF (in vitro fertilization) success rates.
Scientific evidence suggests that these 6 key ingredients at specific dosages contribute to improved fertility. Principal 6 Fertility used this research to produce the most practical, cost-effective, yet clinically superior fertility product on the market.

How Our 6 Core Ingredients Improve Fertility

Ingredient Dose Science
5-DHEA 75 mg The best studies look at using 75mg. Improves egg quality, improves birth rate, improved IVF cycles, beneficial effect on ovarian reserves
CoEnzyme Q10 200 mg Improves ovarian response and semen quality (when men take it)
Myo-Inositol 2000 mg Helps support ovulatory function, improves egg quality
Tetra-hydrofolate (best formulation of folic acid) 900 mcg Improves embryo implantation and decreases risk birth/brain defects in growing fetus; ladies need folic acid, tetra-hydrofolate is just the best formulation
Vitamin D3 2000 IU Increases pregnancy rates and ovulatory function – particularly in IVF cycles; Vit D receptors are found in reproductive tissues: so it helps regulate any metabolic disturbances that can effect pregnancy.
Krill Oil (best source of Omega 3 fatty acids) 917 mg Increases pregnancy rates and ovulatory function

In comparison to other fertility supplements on the market, Principal 6 Fertility provides women with the key ingredients scientifically shown to significantly improve fertility.

Principal 6 Compared

Research Data for the Ingredients of Principal 6 Fertility Supplement

Has been shown to have improved embryo quality (particularly in women with poor ovarian reserves) & Have higher live birth rates

  1. A. Wiser*, O. Gonen, Y. Ghetler, T. Shavit, A. Berkovitz and A. Shulman. Addition of dehydroepiandrosterone (DHEA) for poor-responder patients before and during IVF treatment improves the pregnancy rate: A randomized prospective study. Hum. Reprod. (2010) 25 (10): 2496-2500.
  2. David Barad and Norbert Gleicher. Effect of dehydroepiandrosterone on oocyte and embryo yields, embryo grade and cell number in IVF. Hum. Reprod. (2006) 21 (11): 2845-2849.
  3. David Barad, Hyama Brill, Norbert Gleicher. Update on the use of dehydroepiandrosterone supplementation among women with diminished ovarian function. Journal of Assisted Reproduction and Genetics . December 2007, Volume 24, Issue 12, pp 629-634

Co-Enzyme Q10
Improves Ovarian response & CoQ10 supplementation improves semen quality with beneficial effect on pregnancy rate

  1. E. Burstein, A. Perumalsamy, Y. Bentov, N. Esfandiari, A. Jurisicova, R.F. Casper. Co-enzyme Q10 supplementation improves ovarian response and mitochondrial function in aged mice. Fertility and Sterility, Volume 92, Issue 3, Supplement, Page S31, September 2009
  2. Mohammad Reza Safarinejad. The effect of coenzyme Q10 supplementation on partner pregnancy rate in infertile men with idiopathic oligoasthenoteratozoospermia: an open-label prospective study. International Urology and Nephrology, June 2012, Volume 44, Issue 3, pp 689-700

Helps support ovulatory function & Improves quality of eggs

  1. E. Papaleo, V. Unfer , J.P. Baillargeon, T.T. Chiu. Contribution of myo-inositol to reproduction. European Journal of Obstetrics & Gynecology and Reproductive Biology, Volume 147, Issue 2 , Pages 120-123, December 2009

Though the recommendation for pregnancy is 400-600mcg of folate/folic acid, this is the minimal amount needed to prevent birth defects. But 800-1200 mcg of tetrahydrofolate is best.

Vitamin D3 and Krill Oil
Anti-oxidant properties to help with ovulatory function & improved IVF and pregnancy success

  1. Sebiha Ozkan, M.D.a, Sangita Jindal, Ph.D.b,, Keri Greenseid, M.D.b, Jun Shu, M.D.c, Gohar Zeitlian, M.D.b, Cheryl Hickmon, B.S.b, Lubna Pal, M.B., B.S. Replete vitamin D stores predict reproductive success following in vitro fertilization. Fertility and Sterility, Volume 94, Issue 4, September 2010, Pages 1314–1319